Electronic cigarettes: age-specific generation-resolved pulmonary doses

Abstract

Particle size-number distributions of aerosol from e-cigarettes (0 and 14 mg mL⁻¹ nicotine) were compared with conventional cigarettes. Results were used to provide age-specific (9–21 years) dosimetry estimates applying the MMPD model. After a 2-s puff, total number doses (D _Tot ) were highest for 9 years of age (6.01 × 10¹⁰–1.31 × 10¹¹ particles) and lowest for 18 years of age (4.69 × 10¹⁰–1.06 × 10¹¹ particles). Such doses represented about 19–45 and 25–100% of the relevant daily doses of not smoking individuals, respectively, in tracheobronchial (TB) and alveolar (A) regions. D _Tot for the e-cigarettes were about double that for conventional cigarette. Deposition densities and daily volume of e-cigarette liquid deposited per unit surface area were maximum at lobar bronchi, highest for 9 years and lowest for 21 years age.

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