[Changes in biological functions of high-density lipoprotein after abnormal modification].

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[Changes in biological functions of high-density lipoprotein after abnormal modification].

Sheng Li Xue Bao. 2017 Apr 25;69(2):225-234

Authors: Qu H, Yu Y, Qin SC, Song GH

Abstract
High-density lipoprotein (HDL) is composed of apolipoproteins, lipids and functional proteins. HDL protects against atherosclerosis (AS) by reverse cholesterol transport (RCT). HDL inhibits the lipid oxidation, inflammation and restores endothelial function. During systemic inflammation or metabolic disorders, HDL can be modified abnormally and converted to a dysfunctional type, which results in the loss of anti-inflammatory factors including apolipoprotein A-I (apoA-I), paraoxonase (PON) and platelet activating factor acetylhydrolase (PAF-AH), and gains of pro-inflammatory factors such as serum amyloid A (SAA), triglyceride (TG) and oxidative lipid. Therefore, understanding the changes in compositions and biological functions of dysfunctional HDL might help to comprehend its pathogenic mechanism.

PMID: 28435982 [PubMed - in process]

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