Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients.

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Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 May;123(5):591-599

Authors: de Pauli Paglioni M, Gomes Silva W, Pereira J, Migliorati CA, Lopes MA, de Almeida OP, Goes MF, Ribeiro AC, Brandão TB, Santos-Silva AR

Abstract
OBJECTIVE: To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients.
STUDY DESIGN: Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin.
RESULTS: No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups.
CONCLUSION: IV BP therapy does not thicken cementum or change the micromorphology of PDL.

PMID: 28407986 [PubMed - in process]

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