p16(INK4a) : A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule.

p16(INK4a) : A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule.

Head Neck. 2017 Mar 28;:

Authors: Vital D, Holzmann D, Huber GF, Soyka MB, Moch H, Zimmermann DR, Ikenberg K

Abstract
BACKGROUND: The purpose of this study was to analyze the role of p16(INK4a) and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule.
METHODS: Patients diagnosed from 1995 to 2014 were included in this study. Assessment of p16(INK4a) and HPV-DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16(INK4a) positivity was defined as unequivocal nuclear and cytoplasmic staining of ≥70% of the cells, whereas 50%-69% was considered to be a "borderline" result.
RESULTS: There were 46 patients with SCCs of the nasal vestibule, of whom 31 (67.4%) were available for p16(INK4a) and 30 (65.2%) for analysis of HPV. Expression of p16(INK4a) was present in 19.4% and showed coincidence with high-risk HPV (P < .001). Neither p16(INK4a) nor HPV-DNA had significant impact on outcome.
CONCLUSION: Significant immunoreactivity for p16(INK4a) was present in about one-fifth of the samples and figured as a surrogate marker of high-risk HPV infection. There was no influence on outcome.

PMID: 28371015 [PubMed - as supplied by publisher]

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