Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts.

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Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts.

J Breath Res. 2017 Apr 18;:

Authors: Wawrzyniak R, Woźniak A, Gebreyohannes Y, Dykcik B, Schöffski P, Markuszewski M

Abstract
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract, localized mainly in the stomach or small intestine. The metabolomic signature of GIST signature associated with various mutations in KIT gene remains undiscovered and unexplored. The main aim of this pilot study was to determine and compare metabolomic profiles in GIST xenograft models with different genetic background. Metabolomic profiling using gas chromatography coupled with mass spectrometry followed by both univariate and multivariate statistical analyses was applied to select metabolites which differentiate the GIST models studied. Significant differences in the metabolites that were observed were derived mainly from glycolysis, citric acid cycle, glutamine and lipid metabolism. The obtained results may suggest variable metabolomic signatures of tumour possibly related to the different underlying, specific KIT mutations and with potential implications for the biological behaviour and natural course of this rare disease. This study constitutes a proof of concept in GIST and reveals the potential of the metabolomics approach in orphan malignancies.

PMID: 28416775 [PubMed - as supplied by publisher]

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