Dopamine and serotonin levels in cerebrospinal fluid during episodes of Kleine-Levin syndrome

Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia, cognitive disturbances, apathy, derealization, mood disturbances, hyperphagia, hypersexuality and dysautonomia [1]. The etiology of KLS is unknown. Increased dopamine turnover in the cerebrospinal fluid (CSF) was shown in one patient with KLS and was greater in symptomatic than in the asymptomatic period [2]. The dopamine transporter availability decreased in the striatum of a teenager with KLS and was more marked in the symptomatic than in the asymptomatic phase [3].

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