Mathematical modeling of gonadotropin-releasing hormone signaling

Publication date: 5 July 2017
Source:Molecular and Cellular Endocrinology, Volume 449
Author(s): Amitesh Pratap, Kathryn L. Garner, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Craig A. McArdle
Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.



http://ift.tt/2qCW0s7