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We thank Hervier et al1 for providing comments on our article2 characterizing natural killer (NK) cells in the human lung. Based on analysis of CD69 expression, our results suggest that most CD56bright NK cells are tissue-resident, whereas most CD56dim NK cells in the lung circulate.2 Our results also indicate that the total lung NK cell population is largely hypofunctional. Hervier et al1 regret the fact that we studied NK cell functionality only as a whole, that is, regardless of the cells' status as tissue-resident (CD69-expressing) or circulating.

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