Metabolic Flexibility in Health and Disease

Publication date: 2 May 2017
Source:Cell Metabolism, Volume 25, Issue 5
Author(s): Bret H. Goodpaster, Lauren M. Sparks
Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics" technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.

Teaser

Sparks and Goodpaster dissect the factors and mechanisms influencing energy availability and fuel selection during healthy metabolically flexible responses, such as fasting/feeding and rest/exercise. They discuss the beneficial effects of exercise training on metabolic inflexibility and how targeted therapeutic strategies should be aimed at enhancing these metabolic transitions.


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