When Size Matters: How Astrocytic Processes Shape Metabolism

Publication date: 2 May 2017
Source:Cell Metabolism, Volume 25, Issue 5
Author(s): Ariane Sharif, Vincent Prevot
The hypothalamic control of metabolism appears to be a puzzle that cannot be explained by neuronal function alone. Zhang and colleagues (2017) add a few new pieces by demonstrating that astrocytes critically modulate neural circuits controlling energy homeostasis through nutritional-status-dependent morphological plasticity and IKKβ/NF-κB signaling, which modulate extracellular neurotransmitter bioavailability.

Teaser

The hypothalamic control of metabolism appears to be a puzzle that cannot be explained by neuronal function alone. Zhang and colleagues add a few new pieces by demonstrating that astrocytes critically modulate neural circuits controlling energy homeostasis through nutritional-status-dependent morphological plasticity and IKKβ/NF-κB signaling, which modulate extracellular neurotransmitter bioavailability.


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