The Association Between Sedentary Time And Quality Of Life From The Osteoarthritis Initiative: Who Might Benefit Most From Treatment?

Publication date: Available online 20 June 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Daniel Pinto, Jing Song, Jungwha Lee, Rowland W. Chang, Pamela A. Semanik, Linda S. Ehrlich-Jones, Christine A. Pellegrini, Dorothy D. Dunlop
ObjectiveTo investigate the relationship between sedentary behavior and quality adjusted life years (QALY) among participants in the Osteoarthritis Initiative (OAI).Design1794 participants from a prospective multicenter, longitudinal cohort were classified into quantile groups based on average daily sedentary time (most sedentary Q1 >=11.6, 10.7<=Q2<11.6, 9.7<=Q3<10.7, least sedentary Q4<9.7 average daily sedentary hours).InterventionsNone.Main outcome measuresIndividual QALY was estimated over two years from the area under the curve of health-related utility scores derived from the 12-item Short-Form Health Survey versus time. The relationship between baseline sedentary behavior and median two-year QALYs was estimated using quantile regression adjusted for socioeconomic and BMI.ResultsLower QALYs over two years were more frequently found among the most sedentary (Q1, median 1.59), and QALYs increased as time spent in baseline sedentary behavior decreased (median QALY for Q2:1.64, Q3: 1.65, Q4:1.65). The relationship of sedentary time and median QALY change was only significant for the most sedentary Q1 group where an additional hour of sedentary behavior significantly reduced QALY by -0.073 (95% CI: -0.121, -0.025).ConclusionsOur findings suggest individuals with the most extreme sedentary profiles may be vulnerable to additional losses of quality of life if they become more sedentary. Targeting these individuals to decrease sedentary behavior has the potential to be cost-effective.



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