In vivo Zika virus detection in human skin

Abstract

Zika virus (ZIKAV) a Flavivirus mainly transmitted by Aedes aegypti and Aedes albopictus mosquitoes has been responsible for an extensive epidemic affecting people in more than 56 countries since its emergence in Brazil in 2015 (1). Evidence of the neuroinvasiveness and the tropism of ZIKAV for placenta trophoblasts has turned an infection, originally known for its mildness, into a major world public health concern due to the severity and dissemination of associated disorders (i.e.: congenital Zika syndrome and Guillain Barré syndrome) (2). Despite a commonly short viremia of low intensity the spread of ZIKAV infection is primarily due to vectorial transmission rather than to vertical or sexual transmission which have recently been evidenced (3-5).

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