Phenotypic spectrum of Tessier facial cleft number 5

Craniofacial clefts are among the most disfiguring and rare congenital malformations of the face. The exact incidence remains unclear but it is estimated to be 1.43 to 4.85 per 100.000 live births (Kawamoto, 1976) or as more recently reported to be 1.5 to 6.0 live births (Moore, 1996). Among these, orbito-facial clefts constitute approximately 0.22% of the cases and there is consensus that Tessier cleft number 5 is the least common in this subgroup (Natsume et al., 1999).

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