Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders

Publication date: December 2017
Source:Current Opinion in Neurobiology, Volume 47
Author(s): F Birey, AG Kokkosis, A Aguirre
Adult oligodendrocyte progenitor cells are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential during health and disease. Recently, developments in new experimental approaches have brought about several novel insights about NG2-glia and myelinating oligodendrocytes, indicating a diverse toolkit of functions in experience-dependent myelination and homeostasis in the adult CNS. In this review, we summarize some of the topical studies that highlight newly emerging findings implicating oligodendroglia-lineage cells in brain plasticity, homeostasis and pathophysiology of neuropsychiatric disorders.



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