Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A

Publication date: Available online 4 November 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Yu Ke, Wang Wang, Long-Fei Zhao, Jian-Jia Liang, Ying Liu, Xiao Zhang, Kai Feng, Hong-Min Liu
Two series of derivatives with 1,2,3-triazole as heterocyclic moiety of Jiyuan Oridonin A, a new ent-kaurene diterpenoid which was isolated from genus Isodon rubescens, were synthesized and biologically evaluated. All the derivatives possessed good anti-proliferative activities. Among them, compound 8g was found to significantly induce cell apoptosis and cell cycle arrest in MGC-803 via a series of signals activated by the increased intracellular ROS levels.

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