Early-onset childhood atopic dermatitis is related to NLRP2 repression

Publication date: Available online 9 December 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Loreen Thürmann, Konrad Grützmann, Matthias Klös, Matthias Bieg, Marcus Winter, Tobias Polte, Tobias Bauer, Matthias Schick, Melanie Bewerunge-Hudler, Stefan Roeder, Mario Bauer, Dirk K. Wissenbach, Ulrich Sack, Dieter Weichenhan, Oliver Mücke, Christoph Plass, Michael Borte, Martin von Bergen, Irina Lehmann, Roland Eils, Saskia Trump
Early-onset atopic dermatitis (AD) related repression of the immune regulatory NLRP2 is driven by promoter hypermethylation starting already at time of birth providing an early opportunity to modulate innate immunity to potentially mitigate AD development.



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