Feeling Exhausted? Tuning Irf4 Energizes Dysfunctional T Cells

Publication date: 19 December 2017
Source:Immunity, Volume 47, Issue 6
Author(s): Vijaykumar Chennupati, Werner Held
The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.

Teaser

The regulatory mechanisms governing T cell exhaustion remain incompletely understood. Man et al. (2017) and Wu et al. (2017) report that the T cell receptor responsive transcription factor Irf4 promotes T cell exhaustion in chronic viral infection but dampens exhaustion in response to tissue allografts.


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