RAS and PD-L1: A Masters’ Liaison in Cancer Immune Evasion

Publication date: 19 December 2017
Source:Immunity, Volume 47, Issue 6
Author(s): Nicole Glodde, Michael Hölzel
Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA.

Teaser

Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA.


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