Association study of Essential Tremor genetic loci in Parkinson’s disease

Publication date: Available online 6 January 2018
Source:Neurobiology of Aging
Author(s): Jay P. Ross, Sadaf Mohtashami, Etienne Leveille, Amelie M. Johnson, Lan Xiong, Patrick A. Dion, Edward Fon, Yves Dauvilliers, Nicolas Dupre, Guy A. Rouleau, Ziv Gan-Or
A recent Genome-Wide Association Study (GWAS) identified variants associated with Essential Tremor (ET). The current study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET GWAS, and four additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n=717) and controls (n=595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD. None of the variants tested in the current study was significantly associated with PD. Our results do not support a role of ET-associated genetic variants in PD.



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