Prognostic Value of Free Triiodothyronine Level in Patients with Hypertrophic Obstruction Cardiomyopathy.

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Prognostic Value of Free Triiodothyronine Level in Patients with Hypertrophic Obstruction Cardiomyopathy.

J Clin Endocrinol Metab. 2018 Jan 03;:

Authors: Zhang K, Meng X, Wang W, Zheng J, An S, Wang S, Qi Y, Gao C, Tang YD

Abstract
Context: Thyroid hormone acts as a fundamental regulator in cardiovascular homeostasis in pathophysiological conditions.
Objective: This study aims to determine whether thyroid hormone could be an independent predictor of adverse events in patients with hypertrophic obstruction cardiomyopathy (HOCM).
Design, patients and outcome measure: The original cohort consisted of 965 consecutive patients with HOCM who were admitted to Fuwai Hospital from October 2009 to December 2014, and 756 patients completed thyroid functionevaluations. Patients were divided into three groups according to free triiodothyronine (FT3) levels: tertile 1 (<2.81 pg/mL, n=247), tertile 2 (2.81 to 3.11 pg/mL, n=250), tertile 3 (3.12 to 4.09 pg/mL, n=259).
Results: In correlation analysis, FT3 showed significantly positive correlation with left ventricular ejection fraction (r=0.109, p=0.003). After a median follow-up of 44 months, a total of 45 (6.0%) endpoints (all-cause mortality or cardiac transplantation) occurred with rates of 13.4%, 3.6% and 1.2% in tertiles 1, 2 and 3, respectively. Univariate Cox analysis established FT3 as a predictor of endpoint (HR 0.111; 95%CI: 0.065, 0.189; p<0.001). After adjustment for traditional risk factors, the prognostic value of FT3 level was still significant (HR 0.216; 95% CI: 0.083, 0.559; p=0.002). Compared with patients in tertile 3, those in tertile 1 were at a much higher risk of endpoint (HR 4.918; 95% CI: 1.076, 22.485; p=0.040).
Conclusions: FT3 correlated with cardiac function and could serve as an independent predictor of all-cause mortality and cardiac transplantation in patients with HOCM. These results suggest that monitoring thyroid function in HOCM patients is necessary.

PMID: 29304228 [PubMed - as supplied by publisher]

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