Clinical value of 18 FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma.

Clinical value of 18 FDG PET/CT in screening for distant metastases in head and neck squamous cell carcinoma.

Clin Otolaryngol. 2018 Jan 28;:

Authors: Deurvorst SE, Hoekstra OS, Castelijns JA, Witte BI, René Leemans C, de Bree R

Abstract
OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients.
DESIGN: All patients underwent 18FDG PET/CT for the detection of distant metastases.
SETTING: Retrospective single center study.
PARTICIPANTS: Head and neck squamous cell carcinoma patients with high risk factors for distant metastases.
MAIN OUTCOME MEASURES: Accuracy of 18FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard. Comparison of overall survival between patients diagnosed with distant metastases during initial screening and patients diagnosed with distant metastases during follow-up.
RESULTS: In 23 (12%) of the 190 patients 18FDG PET/CT detected distant metastases at screening. Sensitivity and negative predictive value were 46.2% (95% CI 32.6 - 59.7) and 82.6% (95% CI 76.8 - 88.5). No difference in median overall survival from the time of distant metastases detection was found between patients diagnosed with DM during work-up or during follow up.
CONCLUSIONS: In head and neck squamous cell carcinoma patients with high risk factors 18FDG PET/CT has a high negative predictive value for the detection of distant metastases and should be used in daily clinical practice, although the sensitivity is limited when long term follow-up is used as reference standard. This article is protected by copyright. All rights reserved.

PMID: 29377508 [PubMed - as supplied by publisher]

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