Does the additional component of calf-circumference refine metabolic syndrome in Correlating with Cardiovascular Risk?

Does the additional component of calf-circumference refine metabolic syndrome in Correlating with Cardiovascular Risk?

J Clin Endocrinol Metab. 2018 Jan 15;:

Authors: Wu CJ, Kao TW, Chang YW, Peng TC, Wu LW, Yang HF, Chen WL

Abstract
Context: Calf circumference (CC) was a useful anthropometric tool, but there was limited study on the effect of CC on metabolic syndrome (MetS) for cardiovascular risk.
Objective: The objective of our study was to determine whether additional component of CC refined MetS in correlating with cardiovascular, all-cause and cancer mortality.
Design, Setting, Patients, and Interventions: From the 1999-2002 NHANES dataset, we analyzed four types of MetS: WaistMetS (increased waist circumference and ≥ two of four MetS components), CalfMetS (decreased CC and ≥ two of four MetS components), WCRMetS (increased waist-to-calf ratio and ≥ two of four MetS components), and CC plus MetS (decreased CC and ≥ three of five MetS components).
Primary Outcome Measure: The cause-specific hazard ratios were measured categorized by four types of MetS.
Results: For cardiovascular mortality, the adjusted hazard ratios for WaistMetS, CalfMetS, WCRMetS and CC plus MetS were 1.867, 1.871, 1.949, and 2.306, respectively (all P < 0.001). Notably, CalfMetS showed the strongest positive correlation with serum CRP, and WCRMetS had the strongest positive relationship with HOMA-IR.
Conclusions: The additional component of CC into the components of MetS had higher cardiovascular and all-cause mortality risk than traditional definition of MetS.

PMID: 29346655 [PubMed - as supplied by publisher]

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