Abstract: Neutrophilic panniculitis is a relatively rare condition, characterized by predominantly neutrophilic inflammation in the subcutaneous fat. Rarely, neutrophilic panniculitis may be induced by chemotherapeutics or targeted molecular therapies, including the Bruton tyrosine kinase inhibitor ibrutinib. Previously reported cases of ibrutinib-induced panniculitis were suppressed with sustained low-dose steroid therapy while continuing ibrutinib therapy. To our knowledge, self-limiting panniculitis during ibrutinib therapy has not yet been described. We describe a case of self-limiting, neutrophilic panniculitis which developed during ibrutinib therapy. A 78-year-old woman presented to the dermatology clinic with a 3-week history of painful erythematous nodules on her lower extremities which occurred 1 month after initiating ibrutinib therapy for chronic lymphocytic leukemia. Physical examination revealed tender erythematous poorly demarcated subcutaneous nodules on the anterior and posterior aspects of both lower legs. A panniculitis was suspected clinically, and a punch biopsy was performed. Histological evaluation revealed a lobular panniculitis with fat necrosis and infiltrates consisting predominantly of neutrophils. A diagnosis of neutrophilic panniculitis was rendered, which the patient opted not to treat. The eruption waned before resolving spontaneously over the course of 6 months despite continued ibrutinib therapy. This case illustrates panniculitis as an emerging adverse drug reaction after treatment with ibrutinib and that not all cases will require ibrutinib dose adjustment or steroid therapy but rather may be subject to spontaneous resolution.
http://ift.tt/2Ere53y
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Principles of Diffusion Kurtosis Imaging and its R...
- Novel insights into mitochondrial molecular target...
- Confocal calcium imaging analysis of respiratory-r...
- Reduction in endogenous cardiac steroids protects ...
- Intestinal-type adenocarcinoma of the sinonasal tr...
- Lipid metabolism and benzo[a]pyrene degradation by...
- The liver X receptors and sterol regulatory elemen...
- Effect of hypoxia on caveolae-related protein expr...
- Activation of bombesin receptor Subtype-3 by [D-Ty...
- Adrenergic receptor stimulation suppresses oxidati...
- Determination of EPAC2 function using EPAC2 null M...
- Single cell transcriptome sequencing: A new approa...
- Icariin modulates mitochondrial function and apopt...
- Alpha 1 adrenergic receptor-mediated inflammatory ...
- Epidermal growth factor receptor / extracellular s...
- Postprandial regulation of natriuretic peptides in...
- Real world data on the efficacy and safety of apre...
- Outcomes of Donation After Cardiac Death Liver Gra...
- Inequalities in zoster disease burden: a populatio...
- The PARACELSUS score: A novel diagnostic tool for ...
- Sirolimus for treatment of Kaposiform hemangioendo...
- Inequalities in zoster disease burden: a populatio...
- The PARACELSUS score: A novel diagnostic tool for ...
- Sirolimus for treatment of Kaposiform hemangioendo...
- Combining Behavior and EEG Analysis for Exploratio...
- Utility of Radionuclide Bone Scintigraphy in Compl...
- Medical Cannabis for Neuropathic Pain
- High Dose of A Conjugated Linoleic Acid Mixture In...
- Antral Follicle Diameter Variance Within Each Ovar...
- Early Stage Graves’ Disease is Uniformly Accompani...
- Tanshinone IIA Improves Painful Diabetic Neuropath...
- The PCOS Patients differ in Lipid Profile Accordin...
- New findings in non-invasive imaging of cutaneous ...
- Benign and malignant collision tumors of melanocyt...
- Liponeurofibroma: Clinicopathological features and...
- Posterior reversible encephalopathy syndrome secon...
- Correction to: An exotic abscess within the United...
- Carcinoid heart disease revealed by cyanosis with ...
- Burden of atopic dermatitis in Japanese adults: An...
- Case of psoriatic patient who maintains long-term ...
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- Downregulation of SETD8 by MiR-382 is involved in ...
- Knowledge of resting heart rate mediates the relat...
- Electrophysiological individual face adaptation ef...
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- Haptic recognition memory following short-terrm vi...
- Coupling and Segregation of Large-scale Brain Netw...
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- The Power to Choose
- Benefit‐Risk Summary of Regorafenib for the Treatm...
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- Early Gastric Cancer: Clinical Behavior and Treatm...
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- Dry needling versus friction massage to treat tens...
- Evaluating the effect of rain on the fate of polyc...
- Inverse association between MDM2 and HUWE1 protein...
- Unexpected potential protective associations betwe...
- Use of balloon catheter dilation vs. traditional e...
- The Effects of Pressure Biofeedback Training on In...
- A prospective study of the safety and efficacy of ...
- Palliative radiotherapy for locally advanced non-m...
- Clinical significance of soluble programmed cell d...
- Review of the patient positioning reproducibility ...
- Inorganic nanoparticles: a potential cancer therap...
- Biological hydrogen peroxide detection with aryl b...
- Patient Reported Sexual Aid Utilization and Effica...
- Appraisal of late radiation-induced oral microvasc...
- Machine Learning on a Genome-Wide Association Stud...
- Protective effects of flagellin A N/C against radi...
- Sensitization of hypoxic tumors to radiation thera...
- Head and Neck Tumor Control Probability: Radiation...
- Patterns of Failure in Patients with Double Hit or...
- In a Heartbeat: An Assessment of Dynamic Dose Vari...
- Editorial - New perspectives for the action of ste...
- Inverse association between MDM2 and HUWE1 protein...
- The relationship between plasma vascular endotheli...
- Eliminated respiration-coupled oscillations in the...
- Hypothesis: Is there a link between the immune res...
- Attention as the ‘Glue’ for Object Integration in ...
- Insula mediates heartbeat related effects on visua...
- Accelerated long-term forgetting in focal epilepsi...
- Cognitive phenotypes of sequential staging in amyo...
- Arithmetic skills correlate negatively with the ov...
- Blind readers break mirror invariance as sighted do
- Distinct biomarker of continuous transcutaneous va...
- Reshaping the deep brain stimulation trial for tre...
- Rostral anterior cingulate cortex is a structural ...
- Plasticizing and work hardening in phase separated...
- Influence of stress aging process on variants of n...
- Fate of Lu(III) sorbed on 2-line ferrihydrite at p...
- Higher level of GGT during mid-pregnancy is associ...
- Inverse association between MDM2 and HUWE1 protein...
- The role of corticosteroid-binding globulin in the...
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