Unresectable squamous cell carcinoma of upper trachea with long-term survival after concurrent chemoradiotherapy.

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Unresectable squamous cell carcinoma of upper trachea with long-term survival after concurrent chemoradiotherapy.

BMJ Case Rep. 2017 Aug 11;2017:

Authors: Yathiraj PH, Ail S, Singh A, Mamidipudi V

Abstract
Upper tracheal malignancies are rare, and long-term survival is even rarer, especially among the unresectable malignancies. A 66-year-old chronic smoker was diagnosed as a locally advanced, non-metastatic squamous cell carcinoma of the upper trachea. Being unresectable, he was treated with six cycles of concurrent weekly cisplatin and three-dimensional conformal radiotherapy to a dose of 60 Gy in 30 fractions over 6 weeks. Follow-up imaging at 6 and 12 months revealed no disease. Our patient is presently 36 months post-treatment and is disease free without tracheal necrosis, fistula or radiation pneumonitis but developed hypothyroidism and is presently euthyroid. Concurrent chemoradiotherapy appears safe up to 3 years at least without any necrosis and is effective in controlling local disease. Meticulous planning obviates the need for higher technology like motion management techniques or intensity-modulated radiotherapy.

PMID: 28801512 [PubMed - indexed for MEDLINE]

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