Acute psychosocial stress downregulates N-Methyl-d-aspartate receptors (NMDAR) in healthy human skin

Abstract

Psychosocial stress impacts both healthy and diseased skin¹. Whilst acute stress activates the Hypothalamic-Pituitary-Adrenal (HPA) axis, chronic stress induces suppression and impairs wound healing in humans and animals^1,2. Although the underlying pathomechanisms are yet to be fully elucidated, it is clear that a better understanding of the complex relationship between neuroendocrine pathways, the immune system and the skin (the "brain-skin axis") is pivotal to the optimal management of both stress-responsive dermatoses and cutaneous wound healing.

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