Effects of a Lifestyle Intervention During Pregnancy and First Postpartum Year - Findings from the RADIEL study.

Effects of a Lifestyle Intervention During Pregnancy and First Postpartum Year - Findings from the RADIEL study.

J Clin Endocrinol Metab. 2018 Feb 01;:

Authors: Huvinen E, Koivusalo SB, Meinilä J, Valkama A, Tiitinen A, RöNö K, Stach-Lempinen B, Eriksson JG

Abstract
Context: Women with a history of gestational diabetes (GDM) have a seven-fold risk of developing type 2 diabetes.
Objective: To assess the effects of a lifestyle intervention during pregnancy and first postpartum year on glucose regulation, weight retention, and metabolic characteristics among women at high GDM risk.
Design: In the Finnish Gestational Diabetes Prevention study trained study nurses provided lifestyle counselling in each trimester and 6 weeks, 6 and 12 months postpartum.
Setting: Three maternity hospitals in the Helsinki area and one in Lappeenranta.
Patients: In total 269 women with previous GDM and/or a pre-pregnancy BMI ≥ 30 kg/m2 were enrolled before 20 gestational weeks and allocated to either a control or an intervention group. This study includes the 200 participants who attended study visits 6 weeks and/or 12 months postpartum.
Intervention: The lifestyle intervention followed Nordic diet recommendations and at least 150 minutes of moderate exercise was recommended weekly.
Main Outcome Measure: The incidence of impaired glucose regulation (impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes) during the first postpartum year.
Results: Impaired glucose regulation was present in 13.3% of the women in the control and in 2.7% in the intervention group [age-adjusted OR 0.18 (95% CI 0.05, 0.65), p=0.009] during the first postpartum year. There were no differences between the groups in weight retention, physical activity, or diet at 12 months postpartum.
Conclusions: A lifestyle intervention during pregnancy and the first postpartum year reduced successfully the incidence of postpartum impairment in glucose regulation.

PMID: 29409025 [PubMed - as supplied by publisher]

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