Postprandial saturated fatty acids increase the risk of type 2 diabetes: a cohort study in a Chinese population.
J Clin Endocrinol Metab. 2018 Feb 01;:
Authors: Wang Y, Meng X, Deng X, Okekunle AP, Wang P, Zhang Q, Ding L, Guo X, Lv M, Sun C, Li Y
Abstract
Context: Experimental evidence suggests saturated fatty acids (SFA) are associated with insulin resistance (IR), but results from epidemiological studies on fasting SFA-diabetes risk are inconsistent.
Objective: We investigated SFA (fasting and 2h postprandial) profiles and diabetes risk.
Design setting: A total of 8,940 subjects were recruited for the Harbin People's Health Study in 2008. Serum SFA (fasting and 2h postprandial) at baseline in Chinese men and women without diabetes were profiled while type 2 diabetes was ascertained using WHO criteria after 4-7 years of follow-up.
Outcome: Associations between 2h postprandial SFA (2h-SFA) and diabetes.
Results: At baseline, incident cases of diabetes were older with higher body mass index (BMI) and waist circumference (WC). After a mean follow-up of 6.7 years, 658 incident cases of diabetes occurred. After propensity score (PS) computation and inverse probability of treatment weighting (IPTW) estimation, fasting-SFA were unrelated to diabetes risk but IPTW-adjusted odds ratio (OR) and 95% confidence interval (CI) for the highest tertile of postprandial stearic acid (2h-SA), postprandial palmitic acid (2h-PA) and 2h-SFA for diabetes risk were 2.50 (2.08, 3.16), 1.56 (1.23, 2.02) and 1.70 (1.34, 2.17) respectively P-trend<0.0001. Similarly, 2h-SA/fasting-SA, 2h-PA/fasting-PA and 2h-SFA/fasting-SFA ratios [IPTW-adjusted OR (95%CI): 2.94 (2.39, 3.58), 2.31 (1.80, 2.93), and 2.42 (1.91, 3.11), respectively P-trend<0.0001] predicted the diabetes risk.
Conclusions: Higher serum 2h-SFA (but not fasting-SFA) independently predicted diabetes risk.
PMID: 29409024 [PubMed - as supplied by publisher]
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