Publication date: March 2018
Source:Neoplasia, Volume 20, Issue 3
Author(s): Elizabeth M. Matthew, Zhaohai Yang, Suraj Peri, Mark Andrake, Roland Dunbrack, Eric Ross, Wafik S. El-Deiry
Plk2 is a target of p53. Our previous studies demonstrated that with wild-type p53, Plk2 impacts mTOR signaling in the same manner as TSC1, and Plk2-deficient tumors grew larger than control. Other investigators have demonstrated that Plk2 phosphorylates mutant p53 in a positive feedback loop. We investigated Plk2's tumor suppressor functions in relationship to mTOR signaling. Archival specimens from 12 colorectal adenocarcinomas were stained for markers including Plk2, phosphorylated mTOR (serine 2448) and ribosomal S6 (Serine 235/236). We show that Plk2 is expressed in normal colon, with a punctate staining pattern in supranuclear cytoplasm. In colorectal adenocarcinoma, Plk2 demonstrates complete or partial loss of expression. Strong expression of phosphorylated mTOR is observed in the invasive front. Phosphorylated S6 expression partially correlates with phosphorylated mTOR expression but appears more diffuse in some cases. p53 and Ki67 expression is diffuse, in the subset of cases examined. In order to determine whether Plk2 is lost prior to the development of invasive cancer, 8 colon polyps from 6 patients were evaluated for Plk2 expression. All polyps are positive for Plk2. A Cancer Genome Atlas search identified Plk2 mutations to be infrequent in colorectal adenocarcinomas. Neither Plk2 methylation (in the gene body) nor copy number variations correlated with changes in mRNA expression levels. Loss of Plk2 expression along with accentuated expression of phosphorylated mTOR and phosphorylated S6 at the invasive front in some colorectal carcinomas is consistent with previous findings that an interaction between Plk2 and TSC1 / mTOR signaling molecules plays a role in tumor suppression. Plk2 protein expression is lost at the same stage in colorectal carcinogenesis as p53. The p53 dependence of Plk2 loss and tumor suppressor function in relationship to mTOR signaling may have therapeutic implications.
http://ift.tt/2BqFwL5
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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! # Ola via Alexandros G.Sfakianakis on Inoreader
Η λίστα ιστολογίων μου
Τρίτη 13 Φεβρουαρίου 2018
Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling
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- Using a Dihydrofolate Reductase-Based Strategy for...
- Anti-inflammatory activity and gastroprotective ef...
- Neuroprotective effect of Da Chuanxiong Formula ag...
- Beasley’s 1981 paper: The power of a well-designed...
- Asymptomatic facial nodules
- Characterization of oily mature skin by biophysica...
- Asymptomatic facial nodules
- Role of solid lipid nanoparticles as photoprotecti...
- Role of solid lipid nanoparticles as photoprotecti...
- Immunization with phage virus-like particles displ...
- FlaC supplemented with VAA, OmpK or OmpR as bivale...
- Exceptional influenza morbidity in summer season o...
- Turning up the heat: Effect of new vaccine for chi...
- The National Vaccine Advisory Committee at 30: Imp...
- Cost-effectiveness of vaccination against cytomega...
- Vaccination timeliness and co-administration among...
- Editorial Board/Aims and Scope
- Disparities in parental human papillomavirus (HPV)...
- Evaluation on the persistence of anti-HPV immune r...
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- Impact of introduction of the 9-valent human papil...
- Immune parameters to p67C antigen adjuvanted with ...
- Long-term immunogenicity of an initial booster dos...
- Routing dependent immune responses after experimen...
- Editorial Board/Aims and Scope
- The role of timeliness in the cost-effectiveness o...
- The impact of expanded program on immunization wit...
- Antigen-dependent effects of divergent selective b...
- Prevalence of Fructose Malabsorption in Patients W...
- Differential Emotional Processing in Concrete and ...
- Is Memory Better for Objects Than for Separate Sin...
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- Characterization and source identification of fine...
- Effect of Co doping on the magnetic and DC electri...
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- Retina dose as a predictor for visual acuity loss ...
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- Avoiding the Trap of Misdiagnosis: Valuable Teachi...
- [Spino-pelvic sagittal parameters in an asymptomat...
- [Invasive sinonasal papilloma with intracranial in...
- [Mild head injury].
- [Adult Grisel Syndrome and Cervical Skull instabil...
- [Minimally invasive extraforaminal lumbar interbod...
- Recent findings related to immune responses agains...
- Physiologically distinct subpopulations formed in ...
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- Impact of oxytetracycline and bacterial bioaugment...
- Halimeda jolyana (Bryopsidales, Chlorophyta) prese...
- Polyphenol extracts from dried sugarcane inhibit i...
- Proteomic characterization of Withaferin A-targete...
- Proteomic analysis of first trimester maternal ser...
- Impact of cephalosporin restriction on incidence o...
- Low Proportion of Dietary Plant Protein among Athl...
- Differences in Gut Microbiota Profiles between Aut...
- A Missense Mutation in GJA8 Encoding Connexin 50 i...
- Lymphaticovenular anastomosis for breast cancer tr...
- Aesthetic and functional outcomes of radial forear...
- Orchiectomy and letrozole differentially regulate ...
- Delayed Sleep Phase Syndrome and Bipolar Disorder:...
- Integrating plant and animal biology for the searc...
- Mutagenesis: Interactions with a parallel universe
- Cross-sectional associations between maternal self...
- The Great Esophageal Escape: A Case of Extreme Eso...
- Moonlighting? - Consequences of lunar cues on anur...
- The highs and lows of marijuana use in allergy
- Real world evaluation of a mobile health applicati...
- Sleep and Sedative States Induced by Targeting the...
- Examination of Utricular Response Using oVEMP and ...
- Ageing-related aorta remodelling and calcification...
- "Zhonghua Yi Xue Za Zhi"[jour]; +23 new citations
- Vitamin D modulatory effect on cytokines expressio...
- New technique for large mandibular and surrounding...
- Relationship Between Diet and Tinnitus: Korea Nati...
- Ageing-related aorta remodelling and calcification...
- Postoperative Antibiotics Following Cochlear Impla...
- upper respiratory tract infection; +51 new citations
- "Oncol Lett"[jour]; +257 new citations
- Innovative real CSF leak simulation model for rhin...
- Imaging Findings of Jugular Foramen Meningocele in...
- Sequential spinal and intracranial dural metastase...
- Utility of 3D printed models in enhancing the lear...
- Synthesis and characterization of Ag/Bi 2 WO 6 /GO...
- Lead-induced changes of cytoskeletal protein is in...
- Effect of H 2 O on the NO emission characteristics...
- The treatment of anti-phospholipid syndrome: A com...
- Nanofibers of resorcinol–formaldehyde for effectiv...
- Public awareness and knowledge of stuttering in Japan
- Shifting the Focus: The Primary Role of IL-23 in P...
- Do patients with p16-positive oropharyngeal squamo...
- Microbiology and antimicrobial susceptibility of o...
- A purely functional Imaging based approach for tra...
- Novel SGCE mutation in a patient with myoclonus-dy...
- The difficulty of predicting clinical outcome afte...
- Evaluation and management of small dural tears in ...
- Spinal primary central nervous system lymphoma: Ca...
- Rapid progressive visual decline and visual field ...
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