Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas.

Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas.

Clin Neuropathol. 2018 Mar 29;:

Authors: Frazer B, Kearney H, Cryan J, Beausang A, Brett F, Farrell MA, Buckley PG

Abstract
The presence of oligodendroglioma-like areas in pilocytic astrocytoma may give rise to pathologic diagnostic uncertainty. This study aims to determine if the oligodendroglioma-like areas present in some pilocytic astrocytomas (PA) possess the signature 1p/19q codeletion that is characteristic of classical oligodendroglioma. Array comparative genomic hybridization was carried out on 12 PA samples, from which oligodendroglioma-like areas were microdissected and used as the template DNA source. 1p/19q codeletions were not found in any of the oligodendroglioma areas in PAs. We conclude that PAs with oligodendroglioma-like areas do not share the same molecular genetics as classic oligodendroglioma.
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PMID: 29595124 [PubMed - as supplied by publisher]

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