Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Year.

Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Year.

Curr Top Med Chem. 2018 Mar 28;:

Authors: Kummerle AE, Vitorio F, Franco DP, Pereira TM

Abstract
Coumarins are natural products characterized as 1,2 benzopirones widely distributed in plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic procedures allow the discovery of coumarins with expanded chemical space. The ability to exert noncovalent interactions with many enzymes and receptors in live organisms lead the coumarins to exhibit a wide range of biological activities and applications. Then, this manuscript provides an overview of the use of coumarins compounds in Medicinal Chemistry in treating many diseases. Important examples of the last years were selected concerning the activities of coumarins as anticoagulant, anticancer, antioxidant, antiviral, anti-diabetics, anti-inflammatory, antibacterial, antifungal and antineurodegerative agents. Additionally, it was included applications of coumarins as fluorescent sensors for biological systems. Thus, this work aims to contribute for the development of new rational research projects for the treatment and diagnosis of pathologies using coumarin derivatives.

PMID: 29595110 [PubMed - as supplied by publisher]

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