CT angiography evaluation of risk factors for unstable intracranial aneurysms.

CT angiography evaluation of risk factors for unstable intracranial aneurysms.

World Neurosurg. 2018 Mar 19;:

Authors: Wang GX, Gong MF, Wen L, Liu LL, Yin JB, Duan CM, Zhang D

Abstract
PURPOSE: To evaluate risk factors for the instability in intracranial aneurysms (IAs) using computed tomography angiography (CTA).
METHODS: A total of 614 consecutive patients with 661 IAs were reviewed from August 2011 to February 2016. Patients and IAs were divided into stable and unstable groups. In addition to clinical characteristics, IAs characteristics were evaluated by CTA. Multiple logistic regression analysis was used to identify the independent risk factors associated with unstable IAs. Receiver operating characteristic (ROC) curve analysis was performed on the final model, and optimal thresholds were obtained.
RESULTS: Patients' age (odds ratio (OR) 0.946), cerebral atherosclerosis (CA, OR 0.525) and IAs located at the middle cerebral artery (OR 0.473) and internal carotid artery (OR 0.512) are negatively correlated with instability, while IAs with irregular shape (OR 2.157), deep depth (OR 1.557) or large flow angle (FA, OR 1.015) are more likely to be unstable. ROC analysis revealed that the threshold values of the age, depth and FA were 59.5 years, 4.25 mm and 87.8°, respectively.
CONCLUSIONS: The stability of IAs is significantly affected by factors including patients' age and CA. Additionally, shape and location also have an impact on the stability of IAs. Growth into an irregular shape, with a deep depth and a large FA are risk factors for IAs to change from stable to unstable.

PMID: 29567291 [PubMed - as supplied by publisher]

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