Effects of Curcumin on Bone Loss and Biochemical Markers of Bone Turnover in Patients with Spinal Cord Injury.

Effects of Curcumin on Bone Loss and Biochemical Markers of Bone Turnover in Patients with Spinal Cord Injury.

World Neurosurg. 2018 Mar 19;:

Authors: Hatefi M, Ahmadi MRH, Rahmani A, Dastjerdi MM, Asadollahi K

Abstract
BACKGROUND: Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCI). The current study aimed to evaluate the anti-osteoporotic effects of Curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI.
MATERIALS AND METHODS: The current controlled clinical trial was conducted among 100 patients with SCI referred to an Outpatient Clinic of Rehabilitation in Ilam city, Iran in 2013-2015. Intervention group received 110/mg/kg/day Curcumin for six months and control group received placebo. Bone mineral density (BMD) was measured in all patients. The level of procollagen type I N-terminal propeptide (PINP), serum carboxy-terminal telopeptide of type I collagen (sCTx), osteocalcin and bone-specific alkaline phosphates (BALP) were compared before and after study.
RESULTS: BMD indicators of lumbar, femoral neck and total hip in the control group significantly decreased compared to the beginning of study. However, in the Curcumin group, a significant increase was observed in BMD indicators of lumbar, femoral neck and hip at the end of study compared to the beginning. There was also a significant difference between interventional and control groups for the mean BMD of femoral neck and hip at the end of study (0.718 ±0.002 vs. 0.712±0.003 g/cm2 and 0.742±0.031 vs. 0.692±0.016 g/cm2 respectively).
CONCLUSION: Curcumin, via modulation of densitometry indices and bone resorption markers, showed inhibitory effects on the process of osteoporosis. Treatment with Curcumin was significantly associated with a decrease in the osteoporosis progression and bone turnover markers of patients with SCI after six months.

PMID: 29567290 [PubMed - as supplied by publisher]

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