Menopausal hormone therapy is associated with reduced total and visceral adiposity, the OsteoLaus cohort.

Menopausal hormone therapy is associated with reduced total and visceral adiposity, the OsteoLaus cohort.

J Clin Endocrinol Metab. 2018 Mar 27;:

Authors: Papadakis GE, Hans D, Rodriguez EG, Vollenweider P, Waeber G, Marques-Vidal P, Lamy O

Abstract
Context: Following menopause fat mass (FM) and visceral adipose tissue (VAT) increase, while non-bone lean mass (LBM) decreases. Whether menopausal hormone therapy (MHT) reverses these changes remains controversial.
Objective: To assess the effect of MHT on FM, VAT and LBM before and after its withdrawal and evaluate potential confounders.
Design: Cross-sectional study.
Setting: General community.
Patients or Other Participants: Women of the OsteoLaus cohort (50-80 years old) who underwent dual-energy X-ray absorptiometry (DXA) with body composition assessment. After excluding women with estrogen-modifying medications, the 1053 participants were categorized into current (CU), past (PU) and never (NU) MHT users.
Intervention(s): none.
Main Outcome Measure(s): VAT measured by DXA was the primary outcome. We assessed subtotal and android FM, LBM, muscle strength (hand grip) and confounding factors (caloric intake, physical activity, biomarkers).
Results: The groups significantly differed in age, NU<CU<PU. Age-adjusted VAT was lower in CU than PU (p=0.03). CU exhibited lower age-adjusted BMI (-0.9 kg/m2) and a trend for lower FM (-1.3 kg). The 10-year gain of VAT (p< 0.01), subtotal and android FM (p<0.05) was prevented in CU. No difference in LBM or hand grip was detected. No residual effect was detected for PU, including for early MHT discontinuers. The confounding factors did not significantly differ between groups except for higher caloric intake in PU compared with NU.
Conclusions: MHT is associated with significantly decreased VAT, BMI and android FM. No benefit is detected for LBM. The benefits are not preserved in PU, suggesting caution when MHT is discontinued.

PMID: 29596606 [PubMed - as supplied by publisher]

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