Synthesis and Biological Evaluation of the Coumarins Derivatives as Potential Inhibitors of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin.

Synthesis and Biological Evaluation of the Coumarins Derivatives as Potential Inhibitors of the Production of the Pseudomonas aeruginosa Virulence Factor Pyocyanin.

Curr Top Med Chem. 2018 Mar 29;:

Authors: da S M Forezi L, Froes TQ, Cardoso MFC, de Oliveira Maciel CA, Nicastro GG, Baldini RL, Costa DCS, Ferreira VF, Castilho MS, de C da Silva F

Abstract
Antimicrobial resistance (AMR) is a serious problem for the humans since it threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. One way around this problem is to act on the virulence factors, produced by bacteria, which increase their infection effectiveness. In view of these facts, new coumarin derivatives were synthesized and evaluated for their anti-virulence biological activity towards Pseudomonas aeruginosa. The results suggest that coumarin derivatives with a secondary carbon at C-3 position reduces P. aeruginosa growth whereas compounds with one additional substituent have a significant effect over pyocyanin production (10k EC50 7 ± 2 µM; 10l EC50 42 ± 13 µM). Moreover 10k reduces P. aeruginosa motility and biofilm formation, what is compatible with a quorum sensing related mechanism of action.

PMID: 29595112 [PubMed - as supplied by publisher]

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