Glioblastoma survival outcomes at a tertiary hospital in Appalachia: factors impacting the survival of our patients since implementing the Stupp protocol.

Glioblastoma survival outcomes at a tertiary hospital in Appalachia: factors impacting the survival of our patients since implementing the Stupp protocol.

World Neurosurg. 2018 Apr 06;:

Authors: Urhie O, Turner R, Lucke-Wold B, Radwan W, Ahn J, Gyure K, Bhatia S

Abstract
Glioblastoma is a fatal brain cancer with low median and yearly survival rates. The standard of care for treating glioblastoma is gross total resection (GTR) coupled with the Stupp protocol, but various factors influence the interventions undertaken and survival achieved. As health disparities exist in rural areas, survival in these areas need to be assessed in order to understand which factors detract from the successes of these standard medical interventions. We retrospectively determined the impact of age of diagnosis, number of lesions, the molecular marker O6-methylguanine methyltransferase (MGMT), extent of surgery, and completion of the Stupp protocol on survival among patients treated at West Virginia University Hospitals. We found that an age of diagnosis under 60 years, having the MGMT gene methylated, having a unifocal tumor, receiving GTR, adhering to the Stupp protocol, and undergoing a treatment course of GTR followed by the Stupp protocol significantly increased survival. Lastly, we compared our findings to a pre-Stupp study done in West Virginia in 1996. This comparison showed that although overall median survival has not increased, all interventions involving GTR have resulted in a significantly higher survival.

PMID: 29631083 [PubMed - as supplied by publisher]

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