Outpatient penicillin skin testing has greater value in targeted patient populations

β-Lactam allergy is a major component of antimicrobial stewardship today due to its reported associations with increased healthcare costs, drug toxicity, infections with drug-resistant bacteria, and use of less-preferred antibiotic therapies.1,2 It remains the most common reported medication allergy in the United States, with an estimated prevalence of 10%.1 The US Centers for Disease Control and Prevention and the Infectious Disease Society of America, among other institutions, recommend the performance of penicillin skin testing (PST) as part of antimicrobial stewardship.

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