Primary Central Nervous System Hodgkin Lymphoma-like Post-transplant Lymphoproliferative Disorder.

Primary Central Nervous System Hodgkin Lymphoma-like Post-transplant Lymphoproliferative Disorder.

World Neurosurg. 2018 Mar 30;:

Authors: Hori YS, Nagakita K, Ebisudani Y, Aoi M, Fukuhara T, Shinno Y

Abstract
BACKGROUND: Post-transplant lymphoproliferative disorder (PTLD) is a rare condition occurring after organ transplantation. PTLD comprises four subtypes, of which Hodgkin lymphoma (HL)-type and HL-like type (currently included in polymorphic type) account for only about 1%-3% of cases. Primary central nervous system PTLD is also rare, and most cases are Epstein-Barr virus-positive, B-cell PTLD, while no case of HL-like PTLD has yet been documented.
CASE DESCRIPTION: We present a 43-year-old woman who underwent kidney transplantation for IgA nephropathy 14 years previously, and who presented to our Emergency Department with a chief complaint of seizure. Gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI) showed a ring-enhanced mass in the left temporal lobe. She underwent gross total removal of the tumor, and pathological examination revealed findings consistent with HL-like PTLD. She subsequently underwent immunosuppressant reduction, and received postoperative systemic therapy with rituximab and radiation therapy. Follow-up MRI showed no relapse.
CONCLUSION: This represents an extremely rare case of a patient with HL-like PTLD occurring as a primary CNS lesion.

PMID: 29609086 [PubMed - as supplied by publisher]

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