The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

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The role of ketogenic diets in the therapeutic management of adult and paediatric gliomas: a systematic review.

CNS Oncol. 2018 Apr 16;:

Authors: Martin-McGill KJ, Srikandarajah N, Marson AG, Tudur Smith C, Jenkinson MD

Abstract
AIM: We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas.
METHODS: The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors.
RESULTS: No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias. All studies reported overall or progression-free survival; however the effectiveness of KD interventions could not be established. Dietary acceptability was not reported.
CONCLUSION: The effectiveness and acceptability of KDs in the management of gliomas is unknown and high quality randomized controlled trials are needed.

PMID: 29658772 [PubMed - as supplied by publisher]

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