Application of the alteration uptake ratio of 99mTc-MIBI scintigraphy for evaluating the efficacy of neoadjuvant chemotherapy in osteosarcoma patients.

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Application of the alteration uptake ratio of 99mTc-MIBI scintigraphy for evaluating the efficacy of neoadjuvant chemotherapy in osteosarcoma patients.

Hell J Nucl Med. 2018 Jan-Apr;21(1):55-59

Authors: Huang Z, Lou C

Abstract
BACKGROUND: We aimed to semi-quantitatively evaluate using technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy the efficacy of neoadjuvant chemotherapy in osteosarcoma (OS) patients.
SUBJECTS AND METHODS: A hundred and two patients with OS were retrospectively included in this study. All of them underwent 99mTc-MIBI scintigraphy before and after neoadjuvant chemotherapy. Semi-quantitative parameters including the uptake ratio (UR) and alteration of uptake ratio (AUR) were calculated for each patient. According to tumor necrosis rate (TNR), patients were classified into three group: a) Poor response group (grade I, TNR: less than 50%), b) Partial response group (grade II, TNR: 50%-89%) and c) Good response group (grade III, TNR: greater than 90%). The linear regression analysis of the AUR versus TNR was carried out.
RESULTS: Poor response, partial response and good response were found in 30, 52 and 20 patients, respectively. In the poor-response group the URpre and URpost were 1.68±0.44 and 1.83±0.71, respectively and the AUR was -0.02±0.33. In the partial-response group the URpre and URpost were 2.42±1.42 and 1.59±0.71, respectively and the AUR was 0.28±0.18. In the good-response group the URpre and URpost were 2.58±0.61 and 1.21±0.16, respectively and the AUR was 0.46±0.10. There was a statistically significant difference of the AUR between poor-response and partial-response groups (P<0.01) and also between the poor-response and good-response groups (P<0.01). The linear regression analysis of the AUR versus TNR which showed a significantly positive correlation (r=0.76).
CONCLUSION: The AUR was significant after neoadjuvant chemotherapy in the partial-response group and in the good-response group. Furthermore, it exhibited a positive correlation with TNR. All results indicated that 99mTc-MIBI scintigraphy can be used to evaluate neoadjuvant chemotherapy for OS patients.

PMID: 29705817 [PubMed - in process]

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