Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis.

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Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis.

CNS Oncol. 2018 Apr 30;:

Authors: Merfeld EC, Dahiya S, Perkins SM

Abstract
AIM: To evaluate the use of chemotherapy and radiation, and their outcomes for patients with astroblastoma.
PATIENTS & METHODS: This is a retrospective review of patients extracted from the National Cancer Database. We investigated overall survival (OS) using Kaplan-Meier curves. Cox proportional hazards models were used to correlate OS with risk variables and treatments.
RESULTS: OS at 5 years was 79.5%. Patients with high-grade tumors were more likely to receive chemotherapy and radiation. Patients with high-grade astroblastoma who did not receive adjuvant radiation had poor survival.
CONCLUSION: Patients with astroblastoma should be treated with curative intent. Radiation is likely beneficial in high-grade astroblastoma. The exact role of radiation and chemotherapy following surgical resection warrant further investigation.

PMID: 29708401 [PubMed - as supplied by publisher]

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