[Expression of IL-25 and IL-33 and the count of EOS in peripheral blood of children with allergic rhinitis receiving immunotherapy].

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[Expression of IL-25 and IL-33 and the count of EOS in peripheral blood of children with allergic rhinitis receiving immunotherapy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Mar;32(6):443-446

Authors: Fan H, Qin TJ, Ye LS, Li FT, Lin GS, Liang YQ, Qu SH

Abstract
OBJECTIVES: To investigate the expression of IL-25,IL-33 and EOS in children with allergic rhinitis (AR).
METHODS: Ninety-four AR children receiving immunotherapy and 23 healthy people were concluded in the study. The serum levels of IL-25 and IL-33 were detected by Enzyme-linked Immunosorbent Assay (ELISA), and a count of EOS were measured.
RESULTS: The serum levels of IL-25 and IL-33 in the mild group were higher than control group (P<0.05). The count of EOS showed no difference between the mild group and the control group (P>0.05). The serum levels of IL-25 and IL-33 in the severe group were higher than those in mild group (P<0.05). The serum levels of IL-25 and IL-33 in the severe group were higher than control group (P<0.05). The count of EOS in the severe group were higher than those in mild group (P<0.05). The count of EOS in the severe group were higher than those in control group (P<0.05). Spearman test showed the serum levels of IL-25 in the children with AR patients have positive correlation with the serum levels of IL-33 (P<0.05, R=0.238).
CONCLUSIONS: Expression of IL-25 levels, IL-33 levels and the count of EOS in patients with AR are enhanced, which shows that IL-25, IL-33 and the count of EOS are involved in the AR. If we can understand the mechanism of them, it will profound implications for treatment.

PMID: 29737741 [PubMed]

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