[The study of salivary pepsin content and laryngopharyngeal reflux scale in 91 asymptomatic volunteers].

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[The study of salivary pepsin content and laryngopharyngeal reflux scale in 91 asymptomatic volunteers].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Mar;32(6):415-419

Authors: Chen MX, Hou CJ, Chen T, Li YP, Zeng YL

Abstract
OBJECTIVES: To investigate the content of pepsin in salivary, and to assess the laryngophargeal lesions based on the reflux founding score (RFS) scale in asymptomatic volunteers, in order to provide a reference for the diagnosis of laryngopharyngeal reflux.
METHODS: A total of 91 asymptomatic subjects were recruited in this study. Participants provided a fasting saliva specimen for pepsin measurement using enzyme-linked immunoadsorbent assay, completed the reflux symptom index (RSI) assessment and underwent laryngostroboscopic examination using a rigid endoscope. Their RFS were graded according to the laryngeal findings.
RESULTS: The median concentration of pepsin in 91 asymptomatic volunteers was 55.5 μg/L (range 3.53-191.64 μg/L). The mean individuals RSI was 2.24±2.34, and the mean individuals RFS was 5.78±1.74.
CONCLUSIONS: Our data demonstrate that certain concentration of pepsin was detected and showed a higher RFS score in asymptomatic volunteers.

PMID: 29737735 [PubMed]

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