CD8+CD28+ T cells might mediate injury of cardiomyocytes in acute myocardial infarction

Publication date: September 2018
Source:Molecular Immunology, Volume 101
Author(s): Lili Zhang, Zhiyan Wang, Di Wang, Jumo Zhu, Yi Wang
CD8⁺ T cells accumulate in the necrotic myocardium of acute myocardial infarction (AMI). It is unclear whether CD8⁺CD28⁺ T cells, a specific subset of CD8⁺ T cells, contribute to myocardial injury. In this study, 92 consecutive patients with AMI and 28 healthy control subjects were enrolled. The frequency of CD8⁺CD28⁺ T cells in peripheral blood samples was assayed by flow cytometry. Plasma cardiac troponin I (TNI) and left ventricular ejection fraction (LVEF) were determined. Long-term prognosis of the patients was evaluated by major adverse cardiac and cerebrovascular events (MACCE) over a 12-month follow-up period. Our findings indicated that patients with AMI who presented with high numbers of CD8⁺CD28⁺ T cells had an increased infarction size and aggravated ventricular function. We proposed that cytotoxic CD8⁺CD28⁺ T cell-mediated myocardial necrosis may act as a novel and alternative pathway of AMI.



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