Toward Precision Medicine for Neurological and Neuropsychiatric Disorders

Publication date: Available online 7 June 2018
Source:Cell Stem Cell
Author(s): Rebecca M. Gibbs, Scott Lipnick, Joel W. Bateman, Lloyd Chen, Henry C. Cousins, Elizabeth G. Hubbard, Geraldine Jowett, Darren S. LaPointe, Maxine J. McGredy, Michelle N. Odonkor, Giuliana Repetti, Elizabeth Thomas, Lee L. Rubin
The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.

Teaser

The genetic complexity, clinical variability, and inaccessibility of affected tissue in neurodegenerative and neuropsychiatric disorders have largely prevented the development of effective disease-modifying therapeutics. A precision medicine approach that integrates genomics, deep clinical phenotyping, and patient stem cell models may facilitate identification of underlying biological drivers and targeted drug development.


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