Publication date: Available online 28 June 2018
Source:Revista Española de Medicina Nuclear e Imagen Molecular
Author(s): J. Serrano Vicente, E. Parras Castañera, J.R. Infante Torre, J.I. Rayo Madrid, L. García Bernardo, M. Caballero Moreno, A. Martínez Esteve, A. Muñoz Sanz
Introducción y objetivoLos síndromes febriles de origen desconocido (SFOD) son procesos complejos en la práctica hospitalaria. Su manejo incluye una anamnesis y exploración clínica exhaustivas, así como una extensa batería de pruebas. Cuando los resultados son inciertos, las técnicas diagnósticas de imagen como la SPECT/TC con galio-67 (67Ga-SPECT/TC) desempeñan un papel importante. Pretendemos evaluar su papel en el estudio de los SFOD en nuestro medio hospitalario.Material y métodosHemos revisado 57 pacientes con SFOD a los que se realizó una 67Ga-SPECT/TC (32 mujeres y 25 hombres, rango de edad: 32 a 83 años) recogiendo hallazgos gammagráficos, tratamientos empíricos y diagnóstico final. Se obtuvieron valores de sensibilidad, especificidad, valores predictivos positivos y negativos para la 67Ga-SPECT/TC y se compararon con los resultados descritos en la bibliografía para la PET/TC con Flúor-18-desoxiglucosa (18F-FDG PET/TC).ResultadosLos diagnósticos encontrados fueron: infección en 27/57 (47%), enfermedad inflamatoria en el 15/57 (26%), neoplasia en 1/57 (1,75%) y pacientes sin diagnóstico final en 14/57 (24%). Los valores estadísticos de la 67Ga-SPECT/TC fueron: sensibilidad, especificidad, valor predictivo positivo y negativo de 67%, 93%, 97% y 48%, respectivamente, que fueron levemente inferiores a los encontrados para la 18F-FDG PET/TC (86%, 52%, 70% y 92%, respectivamente). El rendimiento diagnóstico encontrado fue superior en aquellos pacientes que carecían de tratamiento empírico.ConclusiónA pesar los valores superiores del 18F-FDG PET/TC, la 67Ga-SPECT/TC es una técnica útil en el manejo de los SFOD. Es recomendable su uso si el primero no está disponible.Introduction and objectiveFebrile syndromes of unknown origin (FSUO) are complex processes in hospital practice. Their management includes an exhaustive medical history and examination, as well as an extensive number of biochemical tests. If these are inconclusive, diagnostic imaging techniques such as SPECT/CT with 67-Gallium Citrate (67Ga-SPECT/CT) could play an important role. We evaluated its role in the management of FSUO in our healthcare area.Material and methodsWe reviewed 57 patients who underwent a 67Ga-SPECT/CT due to a FSUO (32 women and 25 men, age range: 32-83 years old) obtaining scintigraphic findings, previous treatments and final diagnosis. Values of sensitivity, specificity, positive predictive values (VPP) and negative values (NPV) were obtained and compared with the results for PET/CT with 18Fluor-deoxy-glucose (18F-FDG PET/CT) found in the literature.ResultsThe diagnoses found were: infection in 27/57 (47%), inflammatory disease in 15/57 (26%), neoplasm in 1/57 (1.75%) and patients without final diagnosis in 14/57 (24%). The statistical values of 67Ga-SPECT/CT were: sensitivity, specificity, PPV and NPV of 67%, 93%, 97% y 48%, respectively which were slightly lower than those found for the 18F-FDG PET/CT (86%, 52%, 70% and 92%, respectively). The diagnostic yield was 73% which increased to 80% in the patients who lacked empirical treatment.ConclusionDespite the better results of 18F-FDG PET/CT, 67Ga-SPECT/CT behaved as a useful technique in the management of FSUO. It is advisable to use it if 18F-FDG PET/CT is not available.
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Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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SPECT/TC con galio-67 en los síndromes febriles sin foco conocido
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