BRAF V600E expression in juvenile xanthogranuloma occurring after Langerhans cell histiocytosis

Abstract

Histiocytosis are a heterogenous group of diseases resulting from the abnormal proliferation of cells derived from macrophages‐monocytes or dendritic cells at various sites, including bones, soft tissues and skin. Histiocytosis comprises the Langerhans group (L group), including Langerhans cell histiocytosis (LCH), the cutaneous and mucocutaneous histiocytosis (C group), comprising juvenile xanthogranuloma (JXG) and the group of Rosai‐Dorfman disease and related‐histioctytosis (R group). JXG is the most common form of non‐Langerhans cell histiocytosis (nLCH), and generally is self‐limiting and non‐aggressive. Some reports have documented cases of children with LCH who have developed JXG after chemotherapy.

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