Purpose of review The current review describes the role of different types of innate lymphoid cells (ILCs) in the pathogenesis of asthma inflammatory phenotypes by linking findings from murine asthma models with human studies. Novel treatment options are needed for patients with steroid-insensitive asthma. Strategies targeting ILCs, or their upstream or downstream molecules are emerging and discussed in this review. Recent findings In eosinophilic asthma, ILCs, and especially type 2 ILCs (ILC2s), are activated by alarmins such as IL-33 upon allergen triggering of the airway epithelium. This initiates IL-5 and IL-13 production by ILC2, resulting in eosinophilic inflammation and airway hyperreactivity. Type 3 ILCs (ILC3s) have been shown to be implicated in obesity-induced asthma, via IL-1β production by macrophages, leading ILC3 and release of IL-17. ILC1s might play a role in severe asthma, but its role is currently less investigated. Summary Several studies have revealed that ILC2s play a role in the induction of eosinophilic inflammation in allergic and nonallergic asthmatic patients mainly via IL-5, IL-13, IL-33 and thymic stromal lymphopoietin. Knowledge on the role of ILC3s and ILC1s in asthmatic patients is lagging behind. Further studies are needed to support the hypothesis that these other types of ILCs contribute to asthma pathogenesis, presumably in nonallergic asthma phenotypes.
https://ift.tt/2A46syQ
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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- Intralesional Steroids and Compression Devices for...
- Combination Defects of the Nasal Ala and Perialar ...
- Cardiac herniation into pleural space and subcutan...
- Blunt thoracic aortic injury (BTAI)
- the care of patients with rib fractures
- Cardiothoracic Trauma
- Pre- and postadenotonsillectomy nocturnal enuresis...
- Medical Journal of Babylon
- Experimental and Clinical Biosciences
- Association between serum phosphate and iron conce...
- Relationship between body mass index and serum cal...
- Potentially Malignant Disorder and Squamous Cell C...
- Research in Homeopathy
- Opioid Prescribing Practice and Needs in Thyroid a...
- Association of Facility Volume With Positive Margi...
- JAMA Otolaryngology–Head & Neck Surgery
- December Issue Highlights
- Cognitive Behavioral Therapy for Tinnitus Unbound
- Misspelled Surname in Byline and Author Contributions
- Rapidly Enlarging Parapharyngeal Mass
- Characterizing the Normative Voice Tremor Frequenc...
- A Parathyroid Hemangioma of the Retropharynx
- Opioid Prescribing Practice and Needs in Thyroid a...
- Hyperbaric Oxygen Therapy vs Medical Therapy Alone...
- Reduction of Opiates for Ambulatory Surgery
- The Role of Otolaryngologists in Eradicating Human...
- Association of Facility Volume With Positive Margi...
- An Unusual Entity Presenting as Bilateral Cervical...
- Association of Care Processes With Timely, Equitab...
- Validation of Haptic Properties of Materials for E...
- Timely Adjuvant Postoperative Radiotherapy
- Standard Clinical Method vs Patient-Centered Tinni...
- Notice of Retraction for Schietroma et al
- Patient Concerns About Nasal Reconstruction and Im...
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- 2018: The Knee of the Rejuvenation Curve
- Cellular Senescence as the Key Intermediate in Tau...
- Meetings Calendar 2019
- Study finds elevated risk of certain rare blood ca...
- The effect of being African American on atopic der...
- Paraproteinemia and serum protein electrophoresis ...
- Editorial Board
- Erratum
- Allergy and atopy from infancy to adulthood: Messa...
- The microbiome of the nose
- Information for Authors
- Table of Contents
- Information for Readers
- The Gut Microbiome in Food Allergy
- Severe uncontrolled eosinophilic asthma, which res...
- Seasonal exacerbation of eosinophilic esophagitis ...
- “Asthma Biologics: Underuse, Overuse, and Best Use?”
- Vaccine delivery by precipitation (VDBP) induces t...
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- Human papillomavirus 34 associated with bowenoid p...
- Water Exchange With Narrow Band Imaging on Adenoma...
- A Multicenter Phase I/II Trial of APG-115 in P53 W...
- Water Exchange With Narrow Band Imaging on Adenoma...
- A Multicenter Phase I/II Trial of APG-115 in P53 W...
- Is it worth to perform preoperative MRI for breast...
- Quantification of morphometry and intensity featur...
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- Letter to the Editor regarding, “The prognostic ro...
- Comment on, “Survival for HPV-positive oropharynge...
- Sterilization protocol for porous dental implants ...
- Die Rolle der Chirurgie bei Gliomen
- Die Rolle der Positronenemissionstomographie bei G...
- Letter to the Editor: Protein phosphatase 1 subuni...
- Letter to the Editor: Protein phosphatase 1 subuni...
- Focal localization of inflammatory cytokines and n...
- EARLY PROGRAMMING OF ASTHMA AND ALLERGY: IT IS TIM...
- Correction to: What is the predictor of the intrao...
- Psoriatic skin molecular and histopathological pro...
- A tryptophan metabolite of the skin microbiota att...
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