Altered NOX expression does not seem to account for epidermal NLRP3 inflammasome activation in Hidradenitis Suppurativa

Abstract

Hidradenitis Suppurativa (HS)/ acne inversa is defined as a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep‐seated, inflamed lesions in the apocrine gland‐bearing areas of the body, most commonly the axillae, inguinal and anogenital regions (Dessau definition). It is associated with systemic comorbidities and influenced by genetic predisposition while triggering of the disease occurs by environmental factors. Consecutively, innate immune events appear to play a role. Recently, van der Zee et al. reported increased production of the proinflammatory cytokine IL‐1β in HS.

This article is protected by copyright. All rights reserved.

http://bit.ly/2ASg9Rj