AbstractBackground.Patients with low‐grade gliomas (LGGs) with isocitrate dehydrogenase (IDH) mutation (mut) and 1p19q codeletion (codel) have a median overall survival of longer than 10 years. The aim of this study is to assess the role of postsurgical treatments.Subjects, Materials, and Methods.We evaluated patients with LGGs with IDH mut and 1p19q codel; IDH1/2 was performed by immunohistochemistry and quantitative polymerase chain reaction. In all wild‐type cases, we performed next‐generation sequencing. 1p19 codel analysis was performed by fluorescence in situ hybridization.Results.Among the 679 patients, 93 with LGGs with IDH mutation and 1p19q codel were included. Median follow‐up (FU) was 96.1 months. Eighty‐four patients (90.3%) were high risk according to Radiation Therapy Oncology Group criteria. After surgery, 50 patients (53.7%) received only FU, 17 (18.3%) chemotherapy (CT), and 26 (30.1%) radiotherapy (RT) with (RT + CT, 8 patients, 8.6%) or without (RT, 18 patients, 19.4%) chemotherapy. Median progression‐free survival (mPFS) was 46.3 months, 50.8 months, 103.6 months, and 120.2 months in patients with FU alone, with CT alone, with RT alone, or with RT + CT, respectively. Median PFS was significantly longer in patients who received postsurgical treatment (79.5 months, 95% confidence interval [CI]: 66.4–92.7) than patients who received FU (46.3 months, 95% CI: 36.0–56.5). Moreover, mPFS was longer in patients who received RT (alone or in combination with CT, n = 26, 113.8 months, 95% CI: 57.2–170.5) than those who did not (n = 67, 47.3 months, 95% CI: 36.4–58.2). In particular, temozolomide alone did not improve PFS with respect to FU.Conclusion.RT with or without chemotherapy, but not temozolomide alone, could extend PFS in IDH mut 1p19q codel LGGs.Implications for Practice.Low‐grade gliomas with high‐risk features, defined according to Radiation Therapy Oncology Group criteria, receive radiotherapy and/or chemotherapy as postsurgical treatments. Radiotherapy, however, has serious long‐term effects (cognitive impairment), which are to be taken into account in these young patients. Moreover, low‐grade gliomas with isocitrate dehydrogenase mutation and 1p19q codeletion (oligodendrogliomas) have an extremely long survival and a better prognosis. This study suggests that postsurgical treatments prolong the time before tumor progression in patients with good prognosis as well as those with oligodendroglioma. Moreover, temozolomide alone might not be effective in prolonging progression‐free survival.
http://bit.ly/2InBUyK
Σφακιανάκης Αλέξανδρος
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5 Άγιος Νικόλαος
Κρήτη 72100
00302841026182
00306932607174
alsfakia@gmail.com
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Δευτέρα 18 Φεβρουαρίου 2019
Postsurgical Approaches in Low‐Grade Oligodendroglioma: Is Chemotherapy Alone Still an Option?
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- Immunogenetics
- Pediatric Drugs : Pancreatic Enzyme Supplementatio...
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- Oral Oncology
- Seborrheic Keratosis in the Auricle
- Endoscopic Sphenopalatine Artery Ligation
- The Full Moon on February 19th will be the biggest...
- Natural T cell autoreactivity to melanoma antigens...
- Overstory-understory land cover mapping at the wat...
- Assessment of heavy metal pollution in water and s...
- Hyperferritinaemia following intrauterine transfus...
- XCalibur aneurysm occlusion device for the treatme...
- Mycobacterium avium complex infection mimicking lu...
- Recent progress of chemistry as scientific tool fo...
- Zahlreiche Biologika in der Pipeline
- Stadium IV: systemische Therapien
- Inhaltsverzeichnis
- Sind Computeralgorithmen besser als Dermatologen?
- Highlights aus der Dermatologie
- Ungewollter Verlust des Fettgewebes
- Aktinische Keratosen
- Wenn die Kopfhaut juckt
- Derma Update 2018
- Postsurgical Approaches in Low‐Grade Oligodendrogl...
- Recurrent Pneumonitis in Patients with Melanoma Tr...
- Benigne Raumforderung der Glandula parotis – eine ...
- The interactive effect of the season and estuary p...
- Monitoring of pyrrolizidine alkaloids in beehive p...
- Health risk of metal exposure via inhalation of ci...
- Reproduction of Eutropiichthys vacha (Schilbeidae)...
- CME examination
- Systemic Timolol Exposure Following Topical Applic...
- Limitations of generalizability and reproducibilit...
- Secukinumab Drug Survival in Patients with Psorias...
- Inpatient Dermatology Consultations and the July e...
- Healing or stealing: Ethical issues surrounding su...
- Sinonasal Inverted Papilloma: Efficacy of Demucosa...
- Sinonasal Inverted Papilloma: Efficacy of Demucosa...
- Combination of brachytherapy and chemotherapy not ...
- 18 F-FDG and 18 F-FAMT PET-derived metabolic param...
- Sensitivity and specificity of standardised allerg...
- Modulation of cell adhesion and migration through ...
- Subclinical inflammation and depressive symptoms i...
- T‐VEC in advanced Melanoma – Complete response in ...
- T‐VEC in advanced Melanoma – Complete response in ...
- Comparison of Er,Cr:YSGG and diode laser effects o...
- Impact of the radiographic method on treatment dec...
- Naringenin as an opener of mitochondrial potassium...
- Imaging of pH and pO2 gives insight in molecular p...
- Do human dermal adipocytes switch from lipogenesis...
- Correction to: Clinical manifestations of hydropic...
- The representation of a goiter by Renaissance pain...
- Brain Stem and Audio-Vestibular Regulation
- Targeting the Tumor Microenvironment in R/M SCCHN
- Research Evaluating Sports ConcUssion Events - Rap...
- Neoadjuvant Nivolumab for Oral Cancer Combined Wit...
- TopSpin360 in Female Varsity Athletes
- Dry Needling in Chronic Neck Pain.
- Hyperbaric Radiation Sensitization of Head and Nec...
- Commensal Oral Microbiota in H&N Cancer
- Targeting the Tumor Microenvironment in R/M SCCHN
- Research Evaluating Sports ConcUssion Events - Rap...
- Neoadjuvant Nivolumab for Oral Cancer Combined Wit...
- TopSpin360 in Female Varsity Athletes
- Dry Needling in Chronic Neck Pain.
- Hyperbaric Radiation Sensitization of Head and Nec...
- Commensal Oral Microbiota in H&N Cancer
- Brain Stem and Audio-Vestibular Regulation
- Hyperinsulinaemic hypoglycaemia: A new presentatio...
- Lymphomas of the head and neck region: an update
- Oxygen transfer improvement in MBBR process
- Effects of typical modified passivators on speciat...
- Exposure to polycyclic aromatic hydrocarbons and r...
- A comprehensive study on emission and performance ...
- Organ-specific responses to total ammonia nitrogen...
- Preparation and study of a new type of Fe–C microe...
- Comparison of drought indices in the analysis of s...
- Managing the vine mealybug, Planococcus ficus , th...
- Volatility of the alternative energy input prices ...
- Testing the EKC hypothesis for ten US states: an a...
- Effects of rainfall intensities on sediment loss a...
- The impact of nanoparticles zero-valent iron (nZVI...
- Release characteristics of nitrogen and phosphorus...
- Sorption of copper and norfloxacin onto humic acid...
- 2,4-Dichlorophenoxyacetic acid herbicide effects o...
- Threats of organophosphate esters (OPEs) in surfac...
- Preparation of hypercrosslinked amine modification...
- Bacterial indicator reduction in dairy manure usin...
- The need for combination immunotherapy in oncology
- Oleic acid protects insulin-secreting INS-1E cells...
- A decision algorithm to identify patients with hig...
- Assessing image artifacts from radiotherapy electr...
- Influence of external ear occlusion on food percep...
- Proffered abstracts from the 17th Biennial Congres...
- An uncommon presentation of hyperhomocysteinemia a...
- Potential impact of lingual retainers on oral heal...
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