Abstract Sleep maintains the function of the entire body through homeostasis. Chronic sleep deprivation (CSD) is a prime health concern in the modern world. Previous reports have shown that CSD has profound negative effects on brain vasculature at both the cellular and molecular levels, and that this is a major cause of cognitive dysfunction and early vascular ageing. However, correlations among sleep deprivation (SD), brain vascular changes and ageing have barely been looked into....
Mon Aug 03, 2020 03:00
Chronic fatigue in myelodysplastic syndromes: Looking beyond anemia. Crit Rev Oncol Hematol. 2020 Jul 27;154:103067 Authors: Brownstein CG, Daguenet E, Guyotat D, Millet GY Abstract Chronic fatigue is the most common and severe symptom in myelodysplastic syndromes (MDS) and has a strong negative association with health-related quality of life (HRQoL). Despite anemia being the most common objective manifestation of MDS, and the associated link...
Mon Aug 03, 2020 16:32
Effects of silver nanoparticles on T98G human glioblastoma cells. Toxicol Appl Pharmacol. 2020 Jul 30;:115178 Authors: Fuster E, Candela H, Estévez J, Arias AJ, Vilanova E, Sogorb MA Abstract Nanotechnology has been well developed in recent decades because it provides social progress and welfare. Consequently, exposure of population is increasing and further increases in the near future are forecasted. Therefore, assessing the safety of applications...
Mon Aug 03, 2020 16:32
NADPH-quinone oxidoreductase-1 mediates Benzo-[a]-pyrene-1,6-quinone-induced cytotoxicity and reactive oxygen species production in human EA.hy926 endothelial cells. Toxicol Appl Pharmacol. 2020 Jul 30;:115180 Authors: Shukla H, Gaje G, Koucheki A, Lee HY, Sun X, Trush MA, Zhu H, Li YR, Jia Z Abstract Numerous studies conducted in the past have reported deaths in the human population due to cardiovascular diseases (CVD) on exposure to air particulate...
Mon Aug 03, 2020 16:32
The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases. Int Rev Neurobiol. 2020;154:413-436 Authors: Braun M, Iliff JJ Abstract The cerebral vasculature serves as the crossroads of the CNS, supporting exchange of nutrients, metabolic wastes, solutes and cells between the compartments of the brain, including the blood, brain interstitium, and cerebrospinal fluid (CSF). The blood-brain...
Mon Aug 03, 2020 16:32
Endosomal-lysosomal dysfunction in metabolic diseases and Alzheimer's disease. Int Rev Neurobiol. 2020;154:303-324 Authors: Almeida MF, Bahr BA, Kinsey ST Abstract The endosomal-lysosomal pathways and related autophagic processes are responsible for proteostasis, involving complexes between lysosomes and autophagosomes. Lysosomes are a key component of homeostasis, involved in cell signaling, metabolism, and quality control, and they experience...
Mon Aug 03, 2020 16:32
MAM and C99, key players in the pathogenesis of Alzheimer's disease. Int Rev Neurobiol. 2020;154:235-278 Authors: Pera M, Montesinos J, Larrea D, Agrawal RR, Velasco KR, Stavrovskaya IG, Yun TD, Area-Gomez E Abstract Inter-organelle communication is a rapidly-expanding field that has transformed our understanding of cell biology and pathology. Organelle-organelle contact sites can generate transient functional domains that act as enzymatic...
Mon Aug 03, 2020 16:32
Expression and roles of system L amino acid transporters in human embryonal carcinoma cells. Andrology. 2020 Aug 02;: Authors: Chatsirisupachai K, Kitdumrongthum S, Panvongsa W, Janpipatkul K, Worakitchanon W, Lertjintanakit S, Wongtrakoongate P, Chairoungdua A Abstract BACKGROUND: Testicular germ cell tumors (TGCTs) are the most common malignant cancer in young men. Although TGCTs are generally responsive to platinum-based chemotherapy particularly...
Mon Aug 03, 2020 14:01
Increased protein propionylation contributes to mitochondrial dysfunction in liver cells and fibroblasts, but not in myotubes. J Inherit Metab Dis. 2020 Aug 02;: Authors: Lagerwaard B, Pougovkina O, Bekebrede AF, Te Brinke H, Wanders RJA, Nieuwenhuizen AG, Keijer J, de Boer VCJ Abstract Post-translational protein modifications derived from metabolic intermediates, such as acyl-CoAs, have been shown to regulate mitochondrial function. Patients...
Mon Aug 03, 2020 14:01
A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease. Stem Cell Rev Rep. 2020 Aug 01;: Authors: Soder RP, Dawn B, Weiss ML, Dunavin N, Weir S, Mitchell J, Li M, Shune L, Singh AK, Ganguly S, Morrison M, Abdelhakim H, Godwin AK, Abhyankar S, McGuirk J Abstract BACKGROUND: Because of their well-described immunosuppressive...
Mon Aug 03, 2020 14:01
Anticancer and cytotoxic effects of troxerutin on HeLa cell line: an in-vitro model of cervical cancer. Mol Biol Rep. 2020 Aug 01;: Authors: Hassanshahi J, Mirzahosseini-Pourranjbar A, Hajializadeh Z, Kaeidi A Abstract Cervical cancer is one of the grave uterine tumors which leads to death in women worldwide. Troxerutin (TRX) as a bioflavonoid compound has many pharmacological effects such as anti-neoplastic, radioprotective, and anti-cancer....
Mon Aug 03, 2020 14:01
A 28-Day Carbohydrate-Restricted Diet Improves Markers of Cardiovascular Disease in Professional Firefighters. J Strength Cond Res. 2020 Jul 28;: Authors: Waldman HS, Smith JW, Lamberth J, Fountain BJ, Bloomer RJ, Butawan MB, McAllister MJ Abstract Waldman, HS, Smith, JW, Lamberth, J, Fountain, BJ, Bloomer, RJ, Butawan, MB, and McAllister, MJ. A 28-day carbohydrate-restricted diet improves markers of cardiovascular disease in professional firefighters....
Mon Aug 03, 2020 14:01
Precision medicine for pancreatic diseases. Curr Opin Gastroenterol. 2020 Sep;36(5):428-436 Authors: Shelton CA, Whitcomb DC Abstract PURPOSE OF REVIEW: We describe and contrast the strengths of precision medicine with Western medicine, and complex trait genetics with Mendelian genetics. Classic genetics focuses on highly penetrant pathogenic variants in a single gene believed to cause or confer a high risk for well-defined phenotypes. However,...
Mon Aug 03, 2020 14:01
Precision medicine for pancreatic diseases. Curr Opin Gastroenterol. 2020 Jul 27;: Authors: Shelton CA, Whitcomb DC Abstract PURPOSE OF REVIEW: We describe and contrast the strengths of precision medicine with Western medicine, and complex trait genetics with Mendelian genetics. Classic genetics focuses on highly penetrant pathogenic variants in a single gene believed to cause or confer a high risk for well-defined phenotypes. However, a minority...
Mon Aug 03, 2020 14:01
Colonization with the commensal fungus Candida albicans perturbs the gut-brain axis through dysregulation of endocannabinoid signaling. Psychoneuroendocrinology. 2020 Jul 24;121:104808 Authors: Markey L, Hooper A, Melon LC, Baglot S, Hill MN, Maguire J, Kumamoto CA Abstract Anxiety disorders are the most prevalent mental health disorder worldwide, with a lifetime prevalence of 5-7 % of the human population. Although the etiology of anxiety...
Mon Aug 03, 2020 14:01
Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects. Mol Cell Endocrinol. 2020 Jul 30;:110967 Authors: Fujimoto M, Andrew M, Dauber A Abstract Growth hormone (GH) and its mediator, insulin-like growth factor-1 (IGF-1), have long been recognized as central to human growth physiology. IGF-1 is known to complex with IGF binding proteins as well as with the acid labile subunit (ALS) in order to prolong its half-life...
Mon Aug 03, 2020 14:01
Exercise as cardiovascular medicine. Aust J Gen Pract. 2020 08;49(8):483-487 Authors: Garrahy E, Davison K, Hardcastle S, O'Brien J, Pedersen S, Williams A, Radford J Abstract BACKGROUND: Physical inactivity is a major modifiable contributor to the global burden of cardiovascular disease (CVD) morbidity and mortality. OBJECTIVE: In this article, a clinical case study is used to provide practical approaches for general practitioners...
Mon Aug 03, 2020 14:01
1000 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/03PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mon Aug 03, 2020 16:45
Artist’s impression of the thin stream of stars torn from the Phoenix globular cluster, wrapping around the Milky Way (left). Astronomers targeted bright red giant stars (artist’s impression, right) to measure the chemical composition of the disrupted Phoenix globular cluster. (James Josephides, Swinburne Astronomy/)Some two billion years ago, the Milky Way scarfed down a ball of about a million stars until the gravitational pull of our galaxy tore it into a 27,000-light-year-long stellar river....
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Anthony Fauci told Congress on Friday that he was “cautiously optimistic” a vaccine for COVID-19 will be available by the late 2020 or early 2021. (Pexels/)COVID-19 cases continue to escalate in many parts of the United States, particularly southern and southwestern states like South Carolina, Georgia, Florida, and Texas. Over the past couple months, epicenters once confined to parts of the northeast and northwest, have sprung up in many more corners of the country, making it clear that no area in...
Mon Aug 03, 2020 21:03
Bring the stars to you. (David Menidrey via Unsplash/)Outer space is a fascinating place for folks both young and old. We are constantly learning more about its wonders, investigating its boundaries, and learning more about ourselves along the way, which makes it a great subject for you and your child to explore. Whether you already live with a future astronaut or you are looking to introduce something new, there are so many cool, space-themed decorations to fill a room with. Learn more about the...
Mon Aug 03, 2020 20:24
Open sesame. (Austin Kehmeier via Unsplash/)Whether you’re looking to upgrade your kitchen tools or want to try out some new gadgets just for fun, these can openers will be an efficient way to get cooking. What can seem to be such a simple appliance can actually have a big effect on the way dinner goes. Say goodbye to scary sharp edges, rusty mechanism, and sudden pops as your favorite canned ingredients open. An essential piece to add to your kitchen collection, this list includes easy to use, well...
Mon Aug 03, 2020 20:21
Sit back and relax. (Jared Rice via Unsplash /)It’s important to take time for yourself, and a healthy way to do that is with a nice long bath. A long soak is a great way to relax your muscles, warm up your body, and get away from your notifications, work emails, and social obligations. Bring your favorite book, put on a podcast, or just sit back, light a few candles, and take some deep breaths. Adding a bath bomb or two is a great way to customize your soak. Choose your favorite sizes, smells, and...
Mon Aug 03, 2020 20:05
Know your family better. (Tyler Nix via Unsplash/)Your grandfather’s photo albums and hand-drawn family tree is a great way to get a feel for where you come from but a DNA test will give you detailed results beyond your wildest dreams. These kits seem to be all the rage and we understand why. They are a great way to learn more about your ethnic roots, find contemporary relatives, and explore your genetics from the comfort of your home. You would be surprised by the number of available tests you can...
Mon Aug 03, 2020 18:37
Perfect cooks every time. (Amazon/)Sous vide is an innovative cooking process that got its start in the 1960s as a method of preserving food. Meals are vacuum-sealed in plastic and then submerged in boiling water for extended periods, allowing the ingredients to cook thoroughly without the flavors and juices escaping. Sous vide is super easy to set up, and since it’s a form of slow cooking, it’s great for setting and leaving while you do other things. You don’t even need a large unit to get started—a...
Mon Aug 03, 2020 18:27
Listen to the classics. (Jon Tyson via Unsplash/)There has always been something to say for the cassette tape. Even if you didn’t grow up in the age when a No. 2 pencil was essential to ensure you could wind up your unspooled tapes, the odds are you heard about the charm of making a mixtape with the technology. Real effort goes into creating a cassette mix; it isn’t just drag and drop, but instead a methodical, physical process that allows intention to somehow shine through in the end. So now, as...
Mon Aug 03, 2020 17:59
This is the first time Callaway has used AI to design a full range of clubs including irons. (Callaway /)Artificial intelligence may regularly beat humans at games like chess and checkers, but it’s currently helping us out when it comes to golf. Callaway used machine learning throughout the Mavrik line to introduce new design elements, some of which surprised even the veteran members of its 120-person R&D team.Callaway’s AI efforts began with its Flash drivers, which relied on AI to determine...
Mon Aug 03, 2020 17:08
Newspapers and other media outlets haven't given equal coverage to scientists and big businesses when it comes to climate change. (Roman Kraft/Unsplash/)It may seem that the days of false equivalency in climate change journalism are behind us. It’s rare to see a climate change denier or skeptic framed as an “expert” in an article. And that’s for good reason—their opinions run counter to the overwhelming weight of evidence that climate change is real, happening right now, caused by human activities,...
Mon Aug 03, 2020 15:00
RiboMiner: a toolset for mining multi-dimensional features of the translatome with ribosome profiling data. BMC Bioinformatics. 2020 Aug 01;21(1):340 Authors: Li F, Xing X, Xiao Z, Xu G, Yang X Abstract BACKGROUND: Ribosome profiling has been widely used for studies of translation under a large variety of cellular and physiological contexts. Many of these studies have greatly benefitted from a series of data-mining tools designed for dissection...
Mon Aug 03, 2020 13:32
"I want to really crack this nut": an analysis of parent-perceived policy needs surrounding food allergy. BMC Public Health. 2020 Aug 01;20(1):1194 Authors: Abrams EM, Simons E, Gerdts J, Nazarko O, Povolo B, Protudjer JLP Abstract BACKGROUND: In Canada, anaphylaxis-level food allergy constitutes a legal disability. Yet, no nationwide policies exist to support families. We sought to understand what parents of children with food allergy perceive...
Mon Aug 03, 2020 13:08
The role of telehealth during COVID-19 outbreak: a systematic review based on current evidence. BMC Public Health. 2020 Aug 01;20(1):1193 Authors: Monaghesh E, Hajizadeh A Abstract BACKGROUND: The outbreak of coronavirus disease-19 (COVID-19) is a public health emergency of international concern. Telehealth is an effective option to fight the outbreak of COVID-19. The aim of this systematic review was to identify the role of telehealth services...
Mon Aug 03, 2020 13:08
Types and Amounts of Nonnutritive Sweeteners Purchased by US Households: A Comparison of 2002 and 2018 Nielsen Homescan Purchases. J Acad Nutr Diet. 2020 Jul 28;: Authors: Dunford EK, Miles DR, Ng SW, Popkin B Abstract BACKGROUND: Purchases of foods containing nonnutritive sweetener (NNS) alone or in combination with caloric sweeteners (CS) has increased in recent years in the United States. At the same time clinical evidence is emerging of...
Mon Aug 03, 2020 14:41
Intermittent parathyroid hormone promotes cementogenesis via ephrinB2-EPHB4 forward signaling. J Cell Physiol. 2020 Aug 01;: Authors: Li T, Wang H, Lv C, Huang L, Zhang C, Zhou C, Zou S, Duan P Abstract Intermittent parathyroid hormone (PTH) promotes periodontal repair, but the underlying mechanisms remained unclear. Recent studies found that ephrinB2-EPHB4 forward signaling mediated the anabolic effect of PTH in bone homeostasis. Considering...
Mon Aug 03, 2020 16:53
Hyaluronic acid optimises therapeutic effects of hydrogen peroxide-induced oxidative stress on breast cancer. J Cell Physiol. 2020 Aug 01;: Authors: Abbasi A, Pakravan N, Hassan ZM Abstract Distinguishing the multiple effects of reactive oxygen species (ROS) on cancer cells is important to understand their role in tumour biology. On one side, ROS can be oncogenic by promoting hypoxic conditions, genomic instability and tumorigenesis. Conversely,...
Mon Aug 03, 2020 16:53
HomeoboxC6 affects the apoptosis of human vascular endothelial cells and is involved in atherosclerosis. J Cell Physiol. 2020 Aug 01;: Authors: Long X, You G, Wu Q, Zhou Y, Xiao Y, Yu F, Deng S, Mo R, Song F, Huang J, Tian M Abstract Apoptosis of vascular endothelial cells (VECs) is highly important in the occurrence and development of atherosclerosis (AS). HomeboxC6 (HOXC6) is expressed in higher levels in multiple malignant tissues, and it...
Mon Aug 03, 2020 16:53
Interference of gadolinium dechelated from MR contrast agents by calcium signaling in neuronal cells of GnRH. J Cell Physiol. 2020 Aug 01;: Authors: Baykara M, Ozcan M, Bilgen M, Kelestimur H Abstract Contrast agents (CAs) used in magnetic resonance imaging (MRI) are produced by chelating the metal gadolinium (Gd) with organic ligand molecules to form stable complexes. But, Gd3+ may dissociate from the CAs and subsequently might become toxic...
Mon Aug 03, 2020 16:53
Οι χημικές ουσίες που υπάρχουν στο περιβάλλον μπορεί να είναι υπεύθυνες για τις δυσκολίες που αντιμετωπίζουν στον ύπνο ορισμένες γυναίκες κατά την περίοδο της εμμηνόπαυσης. Αυτά υποστηρίζει μια νέα μελέτη, που δημοσιεύθηκε στο Menopause, λαμβάνοντας υπόψιν δεδομένα της Μελέτης Υγείας Μεσήλικων Γυναικών. Η μελέτη αυτή υποδεικνύει ότι η έκθεση σε διάφορα χημικά στοιχεία όπως oι φθαλικοί εστέρες, που βρίσκονται σε εκατοντάδες προϊόντα που χρησιμοποιούμε καθημερινά, σχετίζονται με διαταραχές του ύπνου...
Mon Aug 03, 2020 08:49
Το άρθρο υπογράφουν ο Δρ. Αλέξανδρος Γιακουστίδης MD PhD FRC, Γενικός Χειρουργός με εξειδίκευση στη χειρουργική ογκολογία ήπατος, παγκρέατος, γαστρεντερικού και στη λαπαροσκοπική/ρομποτική χειρουργική και η Ζωή Γεωργιάδου MSc, ψυχολόγος – ψυχοθεραπεύτρια Η ολιστική προσέγγιση στον χειρουργικό ογκολογικό ασθενή είναι εξαιρετικά σημαντική για την επιτυχή έκβαση της θεραπευτικής αντιμετώπισής του. Η διεπιστημονική ομάδα η οποία καλείται να υποστηρίξει τον χειρουργικό ογκολογικό ασθενή, δηλαδή τον...
Mon Aug 03, 2020 08:42
Το «κλειδί» για την έγκαιρη διάγνωση της νόσου Αλτσχάιμερ ενδέχεται να κρύβεται στη μέτρηση της πρωτεΐνης γνωστής ως p-tau217, η οποία εντοπίζεται σε υψηλά επίπεδα στους πάσχοντες από άνοια. Οι ερευνητές διαπίστωσαν πως η μέτρηση της p-tau217 μπορεί να προβλέψει τη νόσο με ακριβεία 96% έως και 20 χρόνια πριν την εκδήλωση συμπτωμάτων. Πρόκεται για ευρήματα εντυπωσιακά και πολλά υποσχόμενα που θα αποτελέσουν τη βάση περαιτέρω έρευνας με την ελπίδα ότι θα οδηγήσουν σε μία εξέταση αίματος που θα «προειδοποιεί»...
Mon Aug 03, 2020 08:17
Επιστημονική ομάδα υπό την εποπτεία του καθηγητή Μανώλη Κογεβίνα ανέλυσε δεδομένα που αντλήθηκαν μέσω του MCC-Spain project και τα οποία αφορούσαν σε περίπου 2.000 ενήλικες στη Βαρκελώνη και τη Μαδρίτη, εκ των οποίων οι 660 έπασχαν από καρκίνο του παχέος εντέρου και οι υπόλοιποι επελέγησαν τυχαία από τον τοπικό πληθυσμό για τις ανάγκες της έρευνας που δημοσιεύεται στο Epidemiology. Τα επίπεδα τεχνητού φωτισμού σε εξωτερικούς χώρους κατά τη διάρκεια της νύχτας καθορίστηκαν με τη χρήση δορυφορικών...
Mon Aug 03, 2020 07:56
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